Ghana will host Nigeria on Thursday, March 24, 2022, in the first leg of the 2022 FIFA World Cup play-off tie.
The match will be played at the Cape Coast Stadium, the Confederation of African Football announced on Tuesday.
The return leg is scheduled for March 27 at the Moshood Abiola National Stadium in Abuja.
The winner will qualify for the World Cup in Qatar later this year.
Ghana are hoping to make a return to the global showpiece after missing out on the 2018 edition.
Nigeria, meanwhile, were in Russia and are confident of a second consecutive appearance.
Ghana on the other hand are without a coach with reports saying London-born Ghanaian Chris Hughton will be named as head coach.