The Black Stars will play Tunisia’s Carthage Eagles in the maiden Round of 16 of the Africa Cup of Nations.
A 2-0 win over Guinea-Bissau in their final Group F game ensured that the Stars play the runners-up of Group E.
Tunisia picked the runners-up position in their group after drawing all their group games. They were second to Mali, who are yet to lose in the tournament.
Ghana and Tunisia, with six titles between them, will face off on Monday at the Ismailia Stadium, where the four-time champions drew their two opening games.
That match will be the final last 16 game for the tournament.
The two sides last met at the quarter-final stage of the 2012 Cup of Nations hosted by Equatorial Guinea and Gabon.
A Dede Ayew goal, while playing as captain in extra-time, gave the Black Stars a 2-1 win over the Eagles.