Mubarak Wakaso, Jojo Wollacott, and Richard Ofori were the most notable omissions from Ghana’s World Cup squad, which was announced on Monday.
The trio were part of the preliminary squad, but were not included in the final squad, which Otto Addo announced in Accra.
Wakaso has been dropped because he does not fit the technical team’s plan, while Wollacott and Ofori are both injured and will not be ready for the tournament, which begins on Sunday, November 20.
Andre Ayew, Thomas Partey, Jordan Ayew, Baba Rahman, Alexander Djiku, Inaki Williams, Tariq Lamptey, and Daniel Amartey are among Otto Addo’s 26-man squad.
The only Ghana Premier League players in the squad are Danlad Ibrahim and Daniel Afriyie Barnieh, with Salis Abdul Samed and Kamal Sowah making their debuts.
Black Stars are set to camp in Abu Dhabi, where they will play their final pre-tournament friendly against Switzerland on Thursday, November 17.
Ghana face Portugal in their World Cup opener on November 24. They are joined in Group H by South Korea and Uruguay.
The four-time African champions have set a semi-final target.
Ghana squad
Goalkeepers: Lawrence Ati-Zigi (St Gallen), Danlad Ibrahim (Asante Kotoko), Abdul Manaf Nurudeen (Eupen).
Defenders: Joseph Aidoo (Celta Vigo), Daniel Amartey (Leicester City), Alexander Djiku (Racing Strasbourg), Tariq Lamptey (Brighton & Hove Albion), Gideon Mensah (Auxerre), Denis Odoi (Club Bruges), Baba Rahman (Reading), Mohammed Salisu (Southampton), Alidu Seidu (Clermont).
Midfielders: Mohammed Kudus (Ajax), Daniel-Kofi Kyereh (Freiburg), Elisha Owusu (Gent), Thomas Partey (Arsenal), Salis Abdul Samed (Lens).
Forwards: Daniel Afriyie (Hearts of Oak), Andre Ayew (Al Sadd), Jordan Ayew (Crystal Palace), Osman Bukari (Red Star Belgrade), Issahaku Abdul Fatawu (Sporting Lisbon), Antoine Semenyo (Bristol City), Kamal Sowah (Club Bruges), Kamaldeen Sulemana (Rennes), Inaki Williams (Athletic Bilbao).