It is unclear what sparked the inferno but officers of the Ghana National Fire Service were dispatched to the scene, TV3 gathers, to fight the fire.
There was little they could do, however, as almost all the property were lost to the fire.
Desperate attempts were made to get the fire from spreading to adjoining buildings like the Barclays Bank Circle Branch and the Shell Filling Station, which was immediately shut for business.
No major casualties were recorded as workers were preparing for business before the disaster struck.
Police have cordoned off the area, which served as a haven for most survivors of the June 3 flood-cum-fire disaster.