Villarreal took everything Juventus had to throw at them before scoring three late goals to dump the Turin giants out of the UEFA Champions League round of 16.
Geronimo Rulli made two good stops from Dusan Vlahovic, who also hit the bar in the first half, but Juventus’ threat ebbed away as the game went on.
Substitute Francis Coquelin was brought down in the area by Daniele Rugani 13 minutes from time and, after consulting the pitchside video monitor, the referee gave a penalty which fellow sub Gerard Moreno managed to squeeze between Wojciech Szczesny and the post.
With Juventus shell-shocked, five minutes from time a corner was flicked on by Serge Aurier and Pau Torres nudged home unopposed from close range.
There was still time for more late action as former Bournemouth forward Arnaut Danjuma scored from the penalty spot in the second minute of stoppage time after the referee penalised Matthijs de Ligt for handball.