The disaster left at least 150 lives lost with many others injured. Thousands were displaced.
The interdenominational service will have in attendance President John Dramani Mahama, Vice President Paa Kwesi Amissah-Arthur, ministers of state and members of the diplomatic corps.
It is expected to involve all Ghanaians, a statement from the Ministry of Communications on Tuesday said.
The service starts at exactly 8:30 Wednesday morning.
It follows a similar one held at the Flagstaff House on Monday with the Vice President calling on all to be cautious of the climate change conditions.
Officiating minister Reverend Dr Paul Frimpong Manso admonished all to use the disaster as a symbol to come together and cease putting political spins on almost every national issue.
By Emmanuel Kwame Amoh|3news.com|Ghana