Holders Hearts of Oak will face second-tier Skyy FC in the quarter-finals of the MTN FA Cup.
Aduana Stars will play King Faisal, while Bechem United tackle Tamale City FC and Dreams FC take on Kotoku Royals.
Each of the eight teams will get GHc6000, GHc1000 worth of MTN Recharge cards, and a part of the gate proceeds.
The games are set to take place on April 13 and 14, 2022.
With St Martins School Park in Daboase banned due to hooliganism, Skyy FC may host Hearts of Oak in Cape Coast.
Skyy FC vs Hearts of Oak SC
Dreams FC vs Kotoku Royals FC
Bechem United FC vs Tamale City FC
Aduana FC vs King Faisal