Medeama FC will kick off their continental journey by hosting Remo Stars in the first leg at their home before travelling to Nigeria for the second leg. The matches are scheduled to take place from 18th to 20th August for the first leg, and 25th to 27th August for the second leg.
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Notably, Medeama's last participation in CAF inter-club competitions was in 2016 when they made it to the group stage, displaying an impressive performance that included eliminating South African giants Mamelodi Sundowns in the playoff.
The winner of the Medeama-Remo Stars tie will face the formidable Guinean side, Horoya AC, in the second round, with the ultimate goal of securing a coveted spot in the group stage of the CAF Champions League.