Justice Blay’s strike in the second half was enough to sink Hearts.
Kosta Papic made key changes to the side that lost to Great Olympics in the Mantse Derby; Richard Atta replaced Richmond Ayi in the goal poles, Larry Sumaila and Kojo Obeng Junior were all handed a start.
Medeama SC head coach Samuel Boadu also made three changes to the side that lost to Karela United in Week 11; Eric Ofori Antwi, Baba Musah and Eric Kwakwa were all handed a start.
The Yellow and Mauves came close infront of goal in the first half failed to score only for Blay to tap in a Bright Enchill low cross minutes later.
Hearts have now lost consecutive games under Papic for the first time this season.
Elsewhere in Accra, league leaders Karela United were held to a goalless game by Legon Cities.
Karela are yet to record an away win this season.
By Francis Hema|3news.com|Ghana
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