Four people have been confirmed dead and 41 sustained serious injuries.
The accident occurred Monday dawn. The drivers of the two vehicles survived whiles the 41 are receiving treatment at the Tema General Hospital.
The Metro Mass bus was heading to Tema from Aflao whiles the tipper truck was from Tema heading in the opposite direction.
The Tema Divisional police are handling investigations and have blamed poor visibility and fatigue as likely reasons behind the accident.
This is the third accident in a month at the same spot on the highway. Two weeks ago three students of the Central University College died while another was injured when their saloon car was involved in an accident around the same spot.