New local lockdown rules for England are due to be announced later.
The Liverpool City Region is expected to face the tightest restrictions under a new “three-tier” system, which will classify regions as being on “medium”, “high” or “very high” alert.
Steve Rotheram, the city region’s mayor, says negotiations have taken place through the night but “no deal” has been agreed yet.
Talks between local leaders in England and Westminster continue.
Liverpool recorded 600 cases per 100,000 people in the week ending 6 October. The average for England was 74.
The Liverpool City Region includes the local authority districts of Halton, Knowsley, Sefton, St Helens and Wirral, as well as Liverpool.
Gyms, casinos and pubs are among the businesses expected to be impacted by the top-level restrictions, with new curbs to be reviewed after a month.
Prime Minister Boris Johnson is chairing a meeting of the emergency Cobra committee “to determine the final interventions”.
He will then announce changes in the Commons, before speaking at a Downing Street press conference at 18:00 BST.
The prime minister is expected to be joined by Chancellor Rishi Sunak and England’s chief medical officer, Prof Chris Whitty.
Tougher measures were introduced in Scotland on Friday, including the closure of pubs and restaurants across the central belt, while the Welsh government has said the next few days could determine if “national measures” are implemented.